Vertiginous Attacks in Meniere's Disease can be Anticipated by Nonlinear Analysis of Posturography

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A characteristic feature of Ménière's disease is the spontaneous occurrence of vertigo attacks, most often without warning. The unpredictability of vertiginous spells is a major threat for uncontrolled or cluster type patients. Nevertheless, it is difficult to predict spells in spite of advances in vestibular research because vestibular tests are not sensitive enough to detect the fine vestibular abnormalities associated with Ménière's disease. In this paper, we show that nonlinear analysis of stabilometry signals can detect a pre-ictal phase preceding the vertiginous spell by means of the dynamical similarity between a reference state and pre-ictal state. Our results confirmed that nonlinear changes in the multi-link network of the postural control system allowed the prediction of 12 out of 17 spells within 3 days (sensitivity: 70.6%). In contrast, the conventional measure showed a lower sensitivity and specificity. Our results are very encouraging to gain a new insight into the mechanism responsible for pre-ictal to ictal transition in inner ear pathophysiology and the corresponding therapeutic implications.

収録刊行物

  • Equilibrium research  

    Equilibrium research 65(1), 35-47, 2006-02-01 

    Japan Society for Equilibrium Research

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各種コード

  • NII論文ID(NAID)
    10021288963
  • NII書誌ID(NCID)
    AN00001485
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03855716
  • データ提供元
    CJP書誌  J-STAGE 
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