Endothelin-1-induced Barrel Rotation : No Direct Modulation of Rat Medial Vestibular Nucleus Neurone Activity by Endothelin-1

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著者

    • 河内 明夫 KAWACHI Akio
    • 九州保健福祉大学薬学部臨床薬学第一講座 First Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    • 柴田 由香里 SHIBATA Yukari
    • 九州保健福祉大学薬学部臨床薬学第一講座 First Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    • 山田 勝士 YAMADA Katsushi
    • 鹿児島大学大学院医歯学総合研究科薬物動態制御学分野 Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University
    • 本屋 敏郎 MOTOYA Toshiro
    • 九州保健福祉大学薬学部臨床薬学第一講座 First Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare

抄録

Fourth ventricular injections of endothelin-1 (30-100 ng) induced rotation along the long axis of the body (barrel rotation) in rats. <i>N</i>-methyl-D-aspartate (NMDA, 1-10 μg), an excitatory amino acid, and muscimol (1-10 μg), a GABA<sub>A</sub> receptor agonist, also evoked barrel rotation. Bath application of NMDA and muscimol on the spontaneous tonic discharge of medial vestibular nucleus (MVN) neurones in rats, showed excitatory and inhibitory responses, respectively. Interestingly, endothelin-1 did not affect the spontaneous discharge rate of MVN neurones when applied either as a 60 s pulse or when the drug was continuously perfused for a period of 5 min. Reciprocal relationship between excitatory and inhibitory inputs, such as glutamate and GABA receptor agonists, for MVN neurones may be crucial in inducing barrel rotation. The results also suggest that the barrel rotation induced by endothelin-1 is mediated by its modulatory effects on indirect pathways to the vestibular nucleus.

収録刊行物

  • Equilibrium research  

    Equilibrium research 66(1), 9-16, 2007-02-01 

    Japan Society for Equilibrium Research

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各種コード

  • NII論文ID(NAID)
    10021289982
  • NII書誌ID(NCID)
    AN00001485
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03855716
  • データ提供元
    CJP書誌  J-STAGE 
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