Oral administration therapy of isosorbide (ISOBIDE) for Meniere's disease: Methods of the medication in cases with different serum osmotic pressure

• Tokumasu Koji

  Kitasato University, School of medicine, Department of Otorhinolaryngology

• Naganuma Hideaki

  Kitasato University, School of medicine, Department of Otorhinolaryngology

• Hashimoto Shin-ichiro

  Kitasato University, School of medicine, Department of Otorhinolaryngology

• Ito Akihiko

  Kitasato University, School of medicine, Department of Otorhinolaryngology

• Wada Masaoki

  Kitasato University, School of medicine, Department of Otorhinolaryngology

• Okamoto Makito

  Kitasato University, School of medicine, Department of Otorhinolaryngology

• Yamane Masaaki

  Toranomon Hospital, Department of Otorhinolaryngology

Bibliographic Information

Other Title

• メニエール病のイソバイド療法：投与法の検討

Abstract

Hyperosmotic solution of isosorbide has been used for treatment of Meniere's disease since Kitahara et al., Larsen et al. and Nozawa et al.. In recent studies reported that ADH is acting to open water channels, AQP-2 at the endlymphatic membrane and may act worse for labyrinthine hydrops. It is important the serum concentration of isosorbide after administration because ADH should be released if the serum osmotic pressure is elevated by isosorbide above more than 2% of normal serum osmotic pressure. In this study the equation predicting isosrbide serum concentration after oral administration was proposed on the basis of the data by Wakiya's report. It was confirmed the serum osmotic pressure remains below the threshold level for increasing ADH secretion by the routine method of 30 ml/once, 3 times every day. However, the method of 30 ml/once, single or two times every day should be recommended when the serum osmotic pressure before the medication is above 289 mOsm/kg.

Journal

• Equilibrium Research

  Equilibrium Research 66 (2), 64-72, 2007

  Japan Society for Equilibrium Research

Keywords

• Serum concentration of idodorbide
• ADH
• AQP-2
• serum osmotic pressure

Details

• CRID: 1390001204949202432
• NII Article ID: 10021290125
• NII Book ID: AN00001485
• DOI: 10.3757/jser.66.64
• ISSN: 1882577X
• ISSN: 03855716
• Web Site: https://search.jamas.or.jp/link/ui/2008053488
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed