上咽頭癌に対する放射線治療と化学療法による交替療法の治療成績 [in Japanese] Clinical Results of Alternating Chemoradiotherapy for Nasopharyngeal Cancer [in Japanese]
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Twenty-six patients with nasopharyngeal cancer treated at Mie University Hospital between 1996 and 2005 were reviewed. The subjects consisted of 18 males and 8 females. The average age was 53.9-years-old. The clinical stage was IIA in 1, IIB in 4, III in 9, IVA in 7, IVB in 2 and IVC in 3. Histological classification by WHO was type I in 5, type II in 17 and type III in 4. Scheduled courses of alternating chemoradiotherapy were planned. A total 30.6-36Gy (1.8-2.0Gy five times per week) was administered between the skull base and supraclavicular fossa. An additional total 26-30Gy was administered over a decreased irradiation field. A total of 3 courses of chemotherapy were also administered. Each course of radiotherapy or chemotherapy was administered alternatively. Alternating chemoradiotherapy were administered in 21 of 26 cases. Of these 21 cases, poor prognoses were predicted in 2 cases demonstrating distant multiple metastases, 2 cases demonstrating invasion of the clivus, and one case demonstrating intracranial invasion. The other 5 cases were treated by conservative radiotherapy or chemotherapy due to their general conditions. The survival rate in the 21 cases treated by alternative chemoradiotherapy was 86.6% at 2 years and 67.8% at 5 years on Kaplan-Meier analysis.
- Pract.Otol. (Kyoto)
Pract.Otol. (Kyoto) 101(4), 281-286, 2008-04-01
The Society of Practical Otolaryngology