小児急性中耳炎起因菌の最近の傾向 Microbial Pathogens in Pediatric Acute Otitis Media : Recent Trend in a Tokyo Hospital
The management of pediatric acute otitis media (AOM) has recently become more difficult due to increasing antibiotic resistance of pathogens. To investigate and clarify the trends of microbes and antibiotic susceptibility significantly contributes to the treatment of AOM. A retrospective chart review was conducted for 123 children with AOM treated between April 2006 and March 2007. Two hundred twenty five samples of middle ear fluid were obtained by tympanocentesis and 39 samples from otorrhea. Of 225 middle ear fluid samples, 156 samples (69%) were positive on microbial culture and 196 isolates were detected. Thirty isolates were penicillin G susceptible streptococcus pneumoniae (PSSP) and 53 were penicillin G intermediately resistant streptococcus pneumoniae (PISP). There were no penicillin G resistant streptococcus (PRSP). Thirty eight haemophilus influenzae were beta-lactamase non-producing ampicillin susceptible (BLNAS), 15 were beta-lactamase non-producing ampicillin resistant (BLNAR), 13 were beta-lactamase producing ampicillin resistant (BLPAR). There were no beta-lactamase producing ampicillin and clavulanate acid resistant (BLPACR). Of 39 otorrhea samples, 33 samples (85%) were positive on microbial culture and 60 isolates were detected. Two isolates were PSSP and 10 were PISP. There were no PRSP. Eleven were BLNAS, and one was BLNAR. There were no BLPAR or BLPACR. These findings suggest that relatively high proportions of pathogens isolated from AOM in our institute were susceptible to amoxicillin.
耳鼻咽喉科臨床 101(6), 431-434, 2008-06-01
The Society of Practical Otolaryngology