エダラボン局所投与法の内耳への影響 A study for the influence of inner ear application of edaravone
The aim of study was to evaluate the safety of edaravone applied into the inner ear of the guinea pig, as assessed physiologically and morphologically.<BR>Edaravone (6mg/ml)-soaked Gelform pieces were put on the round window membrane of guinea pigs in the right ear. Before and 7 days after treatment, each animal was studied auditory brainstem response (ABR) and caloric test. After physiological examination, ampulla of the lateral semicircular canal, utricle and cochlea were investigated morphologically. No significant ABR threshold shift was observed in the animals between before and 7 days after treatment. No significant difference was found in the caloric response time between the right and left side 7 days after treatment. Seven days after treatment, no obvious morphological change in the vestibular and cochlear endorgans was observed in all animals.<BR>These results suggested that the topical application of edaravone to the inner ear induces no obvious tissue damage physiologically and morphologically.
- Otology Japan
Otology Japan 16(5), 617-621, 2006-12-25
THE JAPAN OTOLOGICAL SOCIETY