骨吸収からみた中耳疾患の病態について : OPGノックアウトマウスを用いた検討から The mechanism of bone resorption in middle ear diseases

この論文にアクセスする

この論文をさがす

著者

    • 神崎 晶 KANZAKI Sho
    • 慶應義塾大学医学部耳鼻咽喉科学教室 Department of Otolaryngology Keio University School of Medicine

抄録

Bone mineral density and morphology of the three auditory ossicles, malleus, incus, and stapes, are maintained by osteoclasts and osteoblasts. However, correlation between bone resorptive changes in the ossicles and hearing loss has not been established. In this review, we discuss osteoporotic changes of the auditory ossicles and pathology of middle ear diseases through the study of mice lacking osteoprotegerin (<I>Opg</I><SUP>-/-</SUP>mice), a soluble decoy receptor for the osteoclastogenic cytokine RANKL. All three ossicles in <I>Opg</I><SUP>-/-</SUP>mice showed thinning and shortening compared to wild-type controls. Most notably, the junction between the stapes and the otic capsule was fused in <I>Opg</I><SUP>-/-</SUP>mice unlike in wild-type mice. Furthermore, progressive hearing loss was detected in <I>Opg</I><SUP>-/-</SUP>mice starting at 6 to 15 weeks of age. These data suggest that OPG plays a crucial role as "audioprotegerin" in hearing by protecting the auditory ossicles and otic capsule from osteoclastic bone resorption. We also discuss clinical implications of resorption of the ossicles for middle ear diseases including otosclerosis and cholesteatoma.

収録刊行物

  • Otology Japan  

    Otology Japan 17(3), 168-172, 2007-07-25 

    THE JAPAN OTOLOGICAL SOCIETY

参考文献:  15件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

被引用文献:  1件

被引用文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10021297076
  • NII書誌ID(NCID)
    AN10358085
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09172025
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ