The Effects of Oral Salazosulfapyridine on Arthriris in Psoriasis Patients

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  • Maejima Hideki
    Department of Dermatology, Kitasato University School of Medicine
  • Tanabe Kenichi
    Department of Dermatology, Kitasato University School of Medicine
  • Arai Satoru
    Department of Dermatology, Kitasato University School of Medicine
  • Nagahashi Kazuya
    Department of Dermatology, Kitasato University School of Medicine
  • Shirai Kyoumi
    Department of Dermatology, Kitasato University School of Medicine
  • Aki Ryouichi
    Department of Dermatology, Kitasato University School of Medicine
  • Sato Kanji
    Department of Dermatology, Kitasato University School of Medicine
  • Saito Norimitsu
    Department of Dermatology, Kitasato University School of Medicine
  • Katsuoka Kensei
    Department of Dermatology, Kitasato University School of Medicine
  • Saito Katsuyoshi
    Department of Orthopaedic-surgery, Kitasato University School of Medicine

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Other Title
  • 関節症状を伴った乾癬に対するサラゾスルファピリジン腸溶剤の効能と限界
  • カンセツ ショウジョウ オ トモナッタ カンセン ニ タイスル サラゾスルファピリジン チョウヨウザイ ノ コウノウ ト ゲンカイ

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Abstract

A salazosulfapyridine enteric-coated preparation (SASP) was found to be effective in treating the arthritis of two psoriasis patients. Case 1, a 59-year-old man, was diagnosed with psoriasis arthritis. Because the inflammatory course involving the knee joint differed from the res of his symp synovial fluid was collected through a puncture. A turbid yellowish fluid was obtained, leading to the diagnosis of an infectious patellar cyst. Oral administration of SASP resulted in ameliorating the arthritis, althogh methotrexate was added to the medication to combat an increasingly exaggerating articular deformation. Case 2, a 61-year-old male, suffered from droplet-type psoriasis vulgaris and polyarthritis. SASP administration resulted in eliminating the erythema and articular symptoms. A total of 8 patients with psoriasis and articular symptoms (including the two described above) have been treated with SASP. Based on these experiences and because of its efficacy (as well as its limitations), SASP is proposed for the treatment of psoriasis complicated by arthritis.

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