Spontaneous Resolution of Angioedema with Eosinophilia in an Untreated Case, with a Retrospective Analysis of Treatments Used in 60 Japanese Cases

• Hashimoto Takashi

  Department of Dermatology, Graduate School, Tokyo Medical and Dental University

• Tanaka Tomoko

  Department of Dermatology, Graduate School, Tokyo Medical and Dental University

• Takayama Kaoru

  Department of Dermatology, Graduate School, Tokyo Medical and Dental University

• Satoh Takahiro

  Department of Dermatology, Graduate School, Tokyo Medical and Dental University

• Yokozeki Hiroo

  Department of Dermatology, Graduate School, Tokyo Medical and Dental University

Bibliographic Information

Other Title

• 無治療で自然経過を観察したnon-episodic angioedema with eosinophilia―本邦報告60例についての治療効果の統計と検討―
• ムチリョウ デ シゼン ケイカ オ カンサツシタ non episodic angioedema with eosinophilia ホンポウ ホウコク 60レイ ニ ツイテ ノ チリョウ コウカ ノ トウケイ ト ケントウ

Abstract

A 46-year-old female was referred for investigation of non-pitting edema of the hands and lower legs associated with eosinophilia. Based on laboratory findigs and histopathology of a skin biopsy, the patient was diagnosed as having non-episodic angioedema with eosinophilia. The patient’s symptoms improved without treatment within 12 weeks. The treatments used in 60 cases of non-episodic angioedema with eosinophilia reported from Japan were reviewed. The treatments included: (1) corticosteroids alone, (2) antihistamines or anti-allergic drugs alone, (3) antihistamines or anti-allergic drugs given with corticosteroids, and (4) no medication. On statistical analysis, corticosteroid treatment was effective in improving symptoms and in significantly reducing the duration required for remission. However there were no statistical differences in total disease duration or treatment duration required for obtaining improvement between patients treated with antihistamines or anti-allergic drugs and patients given no medications. Thus, it appears that antihistamines or anti-allergic drugs have no clinical benefits in the treatment of non-episodic angioedema with eosinophilia.

Journal

• The Japanese Journal of Dermatology

  The Japanese Journal of Dermatology 118 (5), 925-931, 2008

  Japanese Dermatological Association

Keywords

• non-episodic angioedema with eosinophilia (NEAE)
• corticosteroids
• antihistamines
• anti-allergic drugs

Details

• CRID: 1390282680713651712
• NII Article ID: 130004714804
• NII Article ID: 10021305692
• NII Book ID: AN00196602
• DOI: 10.14924/dermatol.118.925
• ISSN: 13468146
• ISSN: 0021499X
• NDL BIB ID: 9479868
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9479868
• Web Site: https://search.jamas.or.jp/link/ui/2008277139
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed