Effect of Trp-P-1 on the Growth of Cultured Rat Astrocytes

この論文にアクセスする

この論文をさがす

著者

抄録

The effects of Trp-P-1 (3-amino-1, 4-dimethyl-5H-pyrido [4, 3-b] indole) on the growth of astrocytes were investigated by in vitro culture experiments supplemented with Trp-P-1. Cultured astrocytes were prepared from the brains of 18 days old fetuses of Wistar rats and were incubated in F-10 medium supplemented with fetal calf serum. The growth of astrocytes (9×10<sup>4</sup> cells) cultured with 10μM Trp-P-1 was inhibited, and the numbers of astrocytes were significantly less than the control (in distilled water) at each time interval (P<0.01, P<0.05). When astrocytes were cultured with varying concentrations of Trp-P-1 for 7 days, the cell number decreased in proportion to the increased dose of Trp-P-1. These results indicated that Trp-P-1 can significantly inhibit the astrocytes development in in vitro culture and the inhibition was dose dependent.

収録刊行物

  • Animal science journal  

    Animal science journal 71(3), 305-307, 2000-05-25 

    Japanese Society of Animal Science

参考文献:  20件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

キーワード

各種コード

  • NII論文ID(NAID)
    10021721581
  • NII書誌ID(NCID)
    AA11677214
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13443941
  • NDL 記事登録ID
    5349560
  • NDL 雑誌分類
    ZR22(科学技術--農林水産--畜産)
  • NDL 請求記号
    Z18-348
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ