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- TABUCHI Mihoko
- Yonezawa Women's College of Yamagata Prefecture
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- ITO Jin-ichi
- School of Medicine, Nagoya City. University
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- ISHIDA Tetsuo
- Yonezawa Women's College of Yamagata Prefecture
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- HOSONO Akiyoshi
- Faculty of Agriculture, Shinshu University
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抄録
The effects of Trp-P-1 (3-amino-1, 4-dimethyl-5H-pyrido [4, 3-b] indole) on the growth of astrocytes were investigated by in vitro culture experiments supplemented with Trp-P-1. Cultured astrocytes were prepared from the brains of 18 days old fetuses of Wistar rats and were incubated in F-10 medium supplemented with fetal calf serum. The growth of astrocytes (9×104 cells) cultured with 10μM Trp-P-1 was inhibited, and the numbers of astrocytes were significantly less than the control (in distilled water) at each time interval (P<0.01, P<0.05). When astrocytes were cultured with varying concentrations of Trp-P-1 for 7 days, the cell number decreased in proportion to the increased dose of Trp-P-1. These results indicated that Trp-P-1 can significantly inhibit the astrocytes development in in vitro culture and the inhibition was dose dependent.
収録刊行物
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- 日本畜産学会報
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日本畜産学会報 71 (3), 305-307, 2000
公益社団法人 日本畜産学会
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詳細情報 詳細情報について
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- CRID
- 1390001205196852608
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- NII論文ID
- 10021721581
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- NII書誌ID
- AN00195188
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- ISSN
- 18808255
- 00215309
- 1346907X
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- NDL書誌ID
- 5349560
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可