Effects of Type of Diet and Salinomycin Supplementation on Insulin Secretory Response and Action in Sheep

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Hyperglycemic clamp and hyperinsulinemic euglycemic clamp techniques were used to investigate the effects of type of diet and salinomycin supplementation on the insulin secretory response to glucose and tissue responsiveness to insulin in adult sheep. The sheep were fed a high-roughage and a high-concentrate diet at equal energy intakes with or without 20ppm of salinomycin for 3 weeks. Basal plasma glucose concentrations were unaffected by type of diet or salinomycin supplementation in both glucose clamp experiments. The ratio of plasma insulin increments to glucose infusion rates in the hyperglycemic clamp experiment and the glucose infusion rate in the hyperinsulinemic euglycemic clamp experiment were unaffected by type of diet or salinomycin supplementation. Although the number of data was small in the present study, these results suggest that in sheep salinomycin supplementation has no significant effects on either the insulin secretory response to glucose or on insulin action, regardless of type of diet.

収録刊行物

  • 日本畜産學會報 = The Japanese journal of zootechnical science  

    日本畜産學會報 = The Japanese journal of zootechnical science 71(1), 42-49, 2000-01-25 

    Japanese Society of Animal Science

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各種コード

  • NII論文ID(NAID)
    10021722058
  • NII書誌ID(NCID)
    AN00195188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    1346907X
  • データ提供元
    CJP書誌  J-STAGE 
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