リゾチームとα-ラクトアルブミンによるマウスリンパ球の増殖抑制作用

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タイトル別名
  • Suppressive Effect of Lysozymes and α-Lactalbumins on Mitogen-induced Proliferative Responses of Mouse Lymphocytes
  • Suppressive Effect of Lysozymes and アルファーLactalbumins on Mitogen-induced Proliferative Responses of Mouse Lymphocytes

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This study comparatively evaluated the influence of quail or chicken lysozyme and bovine or human α-lactalbumin at concentrations ranging from 0 to 100μg/ml on proliferative responses of mouse spleen lymphocytes stimulated by lipopolysaccharide, pokeweed mitogen, phytohemagglutinin and concanavalin A. The lysozymes and α-lactalbumins inhibited the mitogen-induced proliferations in a dose-dependent manner, although the magnitude of inhibition depended on the kind of protein or mitogen. The α-lactalbumins revealed a cytotoxicity toward lymphocytes while the lysozymes were inert. The cytotoxicity of bovine α-lactalbumin diminished completely when the protein was reduced S-carboxymethylated, while some inhibitory effects on the PHA-or ConA-induced proliferation remained after the modification. No mitogen combined with the lysozymes and α-lactalbumins, and the mitogen could bind to lymphocytes previously incubated with the lysozymes or α-lactalbumins. Bovine α-lactalbumin linked to murine CD4+ T-lymphocytes, CD8+ T-lymphocytes and monacytes/macrophages, while quail lysozyme bound to only monocytes/macrophages. These results indicate that both the lysozyme and α-lactalbumin suppress the proliferation of mouse spleen lymphocytes via a different specific interaction of lymphocytes and/or macrophages with each protein.

収録刊行物

  • 日本畜産学会報

    日本畜産学会報 69 (11), 1029-1039, 1998

    公益社団法人 日本畜産学会

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