QTL Detection with Single Diallelic Markers in a Paternal Half-sib Family

DOI Web Site 34 References

Bibliographic Information

Other Title
  • 対立遺伝子数2のシングルマーカーによる父方半きょだい家系での量的形質遺伝子座探索
  • QTL Detection with Single Diallelic Mar

Search this article

Abstract

A certain marker allele may co-segregate with a favorable QTL allele in one half-sib family and with an unfavorable QTL allele in a different half-sib family. On the other hand, an elite proven sire forms a large family in dairy cattle population. Diallelic markers of M and m are assumed to be segregating in such a family consisting of an elite proven sire (grandsire), his half-sib sons and his granddaughters. Simple best linear unbiased prediction (BLUP) procedure of sire model was applied treating the expected number of a QTL allele as a covariate in order to detect a QTL segregating in the family. The design was named combined design from the standpoint that genotyping was conducted in three generations in order not to waste the sires genotyped Mm which were uninformative in granddaughter design with single dialellic markers. Daughters records from sires of (MM, mm), (Mm), and (MM, Mm, mm) were treated as granddaughter, daughter and combined designs, respectively. The size of type 1 error probability on the test of the presence of a QTL was compared among daughter, granddaughter and combined designs. Combined design appeared to have the least type 1 error probability in hierarchical pedigree examples. The combined design basing a large elite proven sire family would serve as an initial glance for further detailed QTL deliberation, especially in the case of diallelic markers.

Journal

References(34)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top