肥育豚における静脈内へのエピネフリンの単回負荷による体脂肪動員の評価 Estimation of Body Fat Mobilization by Single Intravenous Administrations of Epinephrine in Growing-Finishing Pigs
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Plasma free fatty acids (FFA) response to single intravenous administrations of epinephrine was investigated in growing-finishing pigs. Four gilts weighing about 65kg were fitted with a jugular catheter a week before the first epinephrine administration trial. Five doses, 0.1, 0.2, 0.4, 0.8, and 1.6μg/kg body weight (μg/kg BW), of epinephrine were intravenously administered through the catheter. Each pig was administered one dose each day, and dose levels were randomly allocated to each animal. Blood samples were drawn through the catheters at -30, -15, 0, 5, 10, 15, 20, 30, 40, 50, 60, 90, and 120 minutes after the epinephrine administration. Area under curve (AUC) of FFA was significantly increased by the epinephrine administrations (P<0.05). The estimated dose producing half-maximal response (ED<sub>50</sub>) and maximal responsiveness (Rmax) for the AUC of FFA were 0.311±0.113μg/kg BW and 573±167 (μEq/l)•min, respectively. From these results, it seems that <i>in vivo</i> mobilization of body fat in growing-finishing pigs can be estimated by single intravenous administrations of epinephrine.
- Nihon Chikusan Gakkaiho
Nihon Chikusan Gakkaiho 69(4), 355-358, 1998-04-25
Japanese Society of Animal Science