石綿の経気道生体影響とバイオマーカーの検索 : ヘムオキシゲナーゼ-1(HO-1)を中心に Pulmonary Effect of Asbestosis and Other Particles : Focus on HO-1 Protein Expression

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著者

    • 村上 昌宏 MURAKAMI Masahiro
    • 産業医科大学 産業生態科学研究所 呼吸病態学 Dept. of Occupational Pneumology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health
    • 長友 寛子 NAGATOMO Hiroko
    • 産業医科大学 産業生態科学研究所 呼吸病態学 Dept. of Occupational Pneumology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health
    • 大神 明 [他] OGAMI Akira
    • 産業医科大学 産業生態科学研究所 呼吸病態学 Dept. of Occupational Pneumology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health
    • 轟木 基 TODOROKI Motoi
    • 産業医科大学 産業生態科学研究所 呼吸病態学 Dept. of Occupational Pneumology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health
    • 廣橋 雅美 HIROHASHI Masami
    • 産業医科大学 産業生態科学研究所 呼吸病態学 Dept. of Occupational Pneumology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health
    • 森本 泰夫 MORIMOTO Yasuo
    • 産業医科大学 産業生態科学研究所 呼吸病態学 Dept. of Occupational Pneumology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

抄録

It is well known that asbestos induced pulmonary inflammation result in fibrosis. Oxidative stress is thought to be one of the pathogenesis of pulmonary fibrosis, and Heme Oxygenase-1 (HO-1) has been linked to process of protecting lung tissue against oxidative stress. <BR>Heme Oxygenase-1 (HO-1) inducible enzyme that catalyzes heme to generate bilirubin, ferritin, and carbon monoxide (CO) and these resolved products immediately protect lung tissue against oxidative stress. To determine whether or not HO-1 can act as a biomarker of lung injury induced by materials, we made serial measurements of HO-1 expression in rat lungs following the intratracheal instillation of several materials (crocidolite, chrysotile, amosite, crystalline silica) . Male Wistar rats were administered 1 mg or 2 mg of materials suspended in saline by a single intratrachally and were sacrificed at 3 days, 1 week, 1 month, 3 months and 6 months of recovery time. The expression of HO-1 in the rat lung was observed by western blot or ELISA analysis. In case of crocidolite, amosite, chrysotile and crystalline silica which cause sever injury, protein levels of HO-1 in the rat lung constantly increased during the recovery time. The pattern of HO-1 expression is different from materials with severe lung injury and mild or moderate lung injury. It suggests that HO-1 can act as a biomarker of lung injury exposed to particles and fibrous materials.

収録刊行物

  • エアロゾル研究 = Journal of aerosol research  

    エアロゾル研究 = Journal of aerosol research 23(1), 15-20, 2008-03-20 

    日本エアロゾル学会

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各種コード

  • NII論文ID(NAID)
    10021918859
  • NII書誌ID(NCID)
    AN10041511
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09122834
  • NDL 記事登録ID
    9427241
  • NDL 雑誌分類
    ZP5(科学技術--化学・化学工業--化学工学)
  • NDL 請求記号
    Z17-1062
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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