微小粒子状物質の生体影響 : 自律神経への影響を測定する The Effect of Ambient Particulate Matter on Cardiovascular Responses
Evidence has been accumulated to show that the particulate matter in polluted air is associated with increased cardiovascular morbidity and mortality. Our studies demonstrated that the effect of single intrataracheal instillation of PM<SUB>2.5</SUB> in Spontaneous Hypertensive Rat (SHR) decreased the heart rate (HR) and increased the parasympathetic nervous activity. Five hours exposure to PM<SUB>2.5</SUB> tended to enhance the lung resistance, leading to a decreased in HR and an increase in parasympathetic nervous activity. There were no significant changes in the sympathetic parameter. These results suggest that the cardiac function may play a role in pathogenesis relating to harmful effect of PM<SUB>2.5</SUB> on SHR. <BR>More comparative study is needed for health effect of PM<SUB>2.5</SUB>, ultrafine particles and nanoparticles.
- エアロゾル研究 = Journal of aerosol research
エアロゾル研究 = Journal of aerosol research 23(3), 187-192, 2008-09-20