Antifungal Substances Isolated from Aspergillus fumigatus IFM 54246, Obtained from a Brasilian soil

• HOSOE Tomoo

  Faculty of Pharmaceutical Sciences, Hoshi University

• WAKANA Daigo

  Faculty of Pharmaceutical Sciences, Hoshi University

• ITABASHI Takeshi

  Faculty of Pharmaceutical Sciences, Hoshi University

• NOZAWA Koohei

  Faculty of Pharmaceutical Sciences, Hoshi University

• OKADA Kaoru

  Núcleo de Pesquisas em Ciências Ambientais, Universidade Católica de Pernambuco

• de CAMPOS TAKAKI Galba Maria

  Núcleo de Pesquisas em Ciências Ambientais, Universidade Católica de Pernambuco

• TAKIZAWA Kayoko

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• YAGUCHI Takashi

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• FUKUSHIMA Kazutaka

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• KAWAI Ken-ichi

  Faculty of Pharmaceutical Sciences, Hoshi University

Bibliographic Information

Other Title

• ブラジル土壌より分離されたアスペルジルス・フミガツスIFM 54246株から得られた抗真菌活性物質

Abstract

In the screening for new antifungal substances against pathogenic filamentous fungi and yeasts, a naturally new compound, 2,4-dihydroxy-3-methylacetophenone (2), was isolated along with tryptoquivaline I (1) from the methylene chloride-methanol (1:1) extract of Aspergillus fumigatus IFM 54246, obtained from a Brasilian soil, screened by possessing the antifungal activity against Aspergillus fumigatus, Aspergillus niger, Candida albicans and Cryptococcus neoformans. The structure of 2 was determined from the analysis of the spectroscopic investigation. Compound 2 showed the broad antifungal activity against A. fumigatus, A. niger, C. albicans, and C. neoformans, whereas tryptoquivaline I (1) showed the inhibition only against A. fumigatus. The main antifungal substance in the extract of the A. fumigatus strain was considered to be compound 2.

Journal

• JSM Mycotoxins

  JSM Mycotoxins 56 (1), 7-10, 2006

  Japanese Society of Mycotoxicology

Keywords

• Aspergillus fumigatus
• 2,4-dihydroxy-3-methylacetophenone
• tryptoquivaline I
• antifungal activity

Details

• CRID: 1390001204786197632
• NII Article ID: 10021919743
• NII Book ID: AN00334513
• DOI: 10.2520/myco.56.7
• ISSN: 18810128
• ISSN: 02851466
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010752091
• Web Site: https://search.jamas.or.jp/link/ui/2007176010
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed