Recent Research Developements in Polymyositis/Dermatomyositis

• OKIYAMA Naoko

  Department of Dermatology, Tokyo Medical and Dental University

• KOHSAKA Hitoshi

  Department of Medicine and Rheumatology, Tokyo Medical and Dental University

Bibliographic Information

Other Title

• 多発性筋炎・皮膚筋炎の研究の発展

Abstract

  The idiopathic inflammatory myopathies, polymyositis (PM) and dermatomyositis (DM), are evaluated as systemic autoimmune diseases without the pathology determined. Past immunohistochemical findings suggested that the effector response is driven predominantly by CD4 T cells and by humoral immunity in DM, and by cytotoxic T cells in PM. However, histological observations of muscle tissue do not necessarily distinguish DM and PM. Thus, the two diseases including amyopathic DM might represent a spectrum of illness in which some patients suffer only from a muscle disease or from a skin disease.<br>   In comparison with research studies on other rheumatic diseases, there are much fewer research studies conducted on PM/DM. The relationship between PM and DM is not clear yet. We reviewed past clinical and basic research on the pathology of PM/DM, including research on relevant T cells, B cells and cytokines.<br>

Journal

• Japanese Journal of Clinical Immunology

  Japanese Journal of Clinical Immunology 31 (2), 85-92, 2008

  The Japan Society for Clinical Immunology

Keywords

• polymyositis/dermatomyositis
• autoantigen
• autoantibody
• animal experiment

Details

• CRID: 1390001204648558080
• NII Article ID: 10021926849
• NII Book ID: AN00357971
• DOI: 10.2177/jsci.31.85
• ISSN: 13497413
• ISSN: 09114300
• Web Site: http://www.jstage.jst.go.jp/article/jsci/31/2/31_2_85/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008199675
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed