Evans syndrome associated with idiopathic mixed-type autoimmune hemolytic anemia

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Other Title
  • 特発性混合型自己免疫性溶血性貧血を呈したEvans症候群
  • 症例報告 特発性混合型自己免疫性溶血性貧血を呈したEvans症候群
  • ショウレイ ホウコク トクハツセイ コンゴウガタ ジコ メンエキセイ ヨウケツセイ ヒンケツ オ テイシタ Evans ショウコウグン

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Abstract

A 60-year-old man was admitted to our hospital with severe anemia and blood findings showed hemolytic anemia. Further serological examination revealed both warm-reactive autoantibody and cold agglutinin against erythrocytes. The cold agglutinin showed a low titer, 1:32 at 4°C, and had a high thermal amplitude of 30°C or higher, resulting in sufficient activity for hemolysis. Since no underlying disorders could be detected, the diagnosis was idiopathic mixed-type autoimmune hemolytic anemia. Although thrombocytopenia (Evans syndrome) subsequently appeared, corticosteroid was extremely effective for both anemia and thrombocytopenia. In this report we describe a rare case of Evans syndrome associated with mixed-type autoimmune hemolytic anemia, which had a dramatic response to corticosteroid therapy.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 49 (7), 516-520, 2008

    The Japanese Society of Hematology

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