Arterial Stiffness, Physical Activity, and Atrial Natriuretic Peptide Gene Polymorphism in Older Subjects

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著者

    • MAEDA Seiji
    • Center for Tsukuba Advanced Research Alliance, University of Tsukuba
    • OTSUKI Takeshi
    • Center for Tsukuba Advanced Research Alliance, University of Tsukuba
    • SUGAWARA Jun
    • Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology
    • KUNO Shinya
    • Institute of Health and Sport Sciences, University of Tsukuba
    • MATSUDA Mitsuo
    • Center for Tsukuba Advanced Research Alliance, University of Tsukuba

抄録

An increase in arterial stiffness with advancing age is associated with several pathological states, includinghypertension and arteriosclerosis. Regular exercise improves the aging-induced increase in arterial stiffnessand has a protective effect against these diseases. However, not all individuals respond to exerciseto the same extent. Atrial natriuretic peptide (ANP) is involved in the regulation of basal blood pressure,blood flow, and vascular tone. The present study was designed to clarify whether gene polymorphisms inANP-related genes affect exercise-induced improvements in arterial stiffness. We performed a cross-sectionalstudy of 291 healthy middle-aged and older Japanese subjects (63±1 years), examining the relationshipbetween daily physical activity–induced improvements in arterial stiffness, estimated by brachial-anklearterial pulse wave velocity (baPWV), and the gene polymorphisms of valine32methionine (V32M: 664G>A)in exon 1 of ANP and asparagine521aspartic acid (N521D: 1780A>G) in exon 8 of the ANP clearance receptor(NPR-C). The baseline baPWV was significantly lower in the active group, but no differences were seen inblood pressure. Active subjects with the ANP-VV genotype had significantly lower baPWV and higherplasma ANP levels compared with inactive subjects, but there were no variations related to the VM+MMgenotype. Additionally, baPWV and plasma ANP levels were negatively correlated in ANP-VV genotypesubjects, but were not correlated in VM+MM individuals. Our results suggest that ANP polymorphismin older Japanese subjects may affect the cardiovascular response to regular exercise.

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension  

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 31(4), 767-774, 2008-04-01 

    the Japanese Society of Hypertension

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各種コード

  • NII論文ID(NAID)
    10021934935
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  IR 
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