C型慢性肝炎に対する interferon 治療の副作用の比較 : 従来型 interferon と peginterferon Comparison of the adverse events to interferon therapy in patients with chronic hepatitis C : standard interferon versus pegylated interferon

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著者

    • 矢倉 道泰 YAGURA Michiyasu
    • 独立行政法人国立病院機構東京病院消化器科 Department of Gastroenterology, National Hospital Organization, Tokyo National Hospital
    • 田中 晃久 TANAKA Akihisa
    • 独立行政法人国立病院機構東京病院消化器科 Department of Gastroenterology, National Hospital Organization, Tokyo National Hospital
    • 井利 雅信 [他] IRI Masanobu
    • 独立行政法人国立病院機構東京病院消化器科 Department of Gastroenterology, National Hospital Organization, Tokyo National Hospital
    • 上司 裕史 KAMITSUKASA Hiroshi
    • 独立行政法人国立病院機構東京病院消化器科 Department of Gastroenterology, National Hospital Organization, Tokyo National Hospital

抄録

We compared the adverse events among the same patients with chronic hepatitis C who were treated with standard interferon (IFN) with no response and again treated with pegylated interferon (PEG-IFN) combined with or without ribavirin (RIB), based on a questionnaire and blood count analysis. Patients were divided into four groups; standard IFN group, standard IFN+RIB group, PEG-IFN group, and PEG-IFN+RIB group. As a result, allergic reactions, such as itching, stomatitis, sneezing were much less seen in the standard IFN group, compared to PEG-IFN group. On the other hand, flu-like symptoms were more seen in the former than the latter. Hemoglobin and neutrophilic leukocyte counts significantly decreased until 16 weeks after starting the therapy in the groups with RIB than the groups without it. Platelet level significantly decreased at 2 weeks in the standard IFN+RIB group compared with PEG-IFN+RIB. As a whole, patients were satisfied with PEG-IFN therapy in view of visiting a doctor only once a week and its physical and mental easiness.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 49(6), 275-278, 2008-06-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10021939015
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • NDL 記事登録ID
    9546593
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z19-130
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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