小児科領域におけるC型慢性肝炎に対するペグインターフェロンα2b+リバビリン併用療法の経験 Pegylated interferon-α2b and ribavirin combination therapy for pediatric patients with chronic hepatitis C

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著者

    • 乾 あやの INUI Ayano
    • 済生会横浜市東部病院こどもセンター肝臓・消化器部門 Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
    • 小松 陽樹 KOMATSU Haruki
    • 済生会横浜市東部病院こどもセンター肝臓・消化器部門 Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
    • 十河 剛 [他] SOGO Tsuyoshi
    • 済生会横浜市東部病院こどもセンター肝臓・消化器部門 Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
    • 橋本 卓史 HASHIMOTO Takuji
    • 済生会横浜市東部病院こどもセンター肝臓・消化器部門 Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital
    • 藤澤 知雄 FUJISAWA Tomoo
    • 済生会横浜市東部病院こどもセンター肝臓・消化器部門 Division of Hepatology and Gastroenterology, Children's Center for Health and Development, Yokohama Eastern Hospital

抄録

Thirteen Japanese children and young adults (age range 10-40 years, median 18 years) with chronic hepatitis C have been treated with pegylated interferon α2b and ribavirin combination therapy in our pediatric center. The HCV RNA levels before treatment were 5-3,900 KIU/ml (median 1,500 KIU/ml), with HCV genotype 1 in 7 patients, 2a in 5, and 2b in 1. Of the 13 patients, 8 have completed the treatment course with sufficient follow-up to date, and 7 (with HCV genotype 1b in 4, 2a in 2 and 2b in 1) of them (88%) have achieved sustained virological response. The major adverse effect related to therapy was fever. This combination therapy was well tolerated in all the patients without cessation of the therapy. Our present results encourage treatment of pediatric hepatitis C patients with pegylated interferon and ribavirin, as in adult patients.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 49(8), 386-388, 2008-08-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10021939447
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • NDL 記事登録ID
    9620412
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z19-130
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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