Three Cases of Mikulicz's Disease as an IgG4-related Disease
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- Nakano Sei-ichi
- Tokushima Red Cross Hospital
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- Yamamoto Motohisa
- Sapporo Medical University
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- Takemura Teiji
- Sakai Municipal Hospital
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- Ishimaru Naozumi
- University of Tokushima School of Dentistry
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- Miyazaki Katsushi
- University of Tokushima
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- Tamura Koichi
- University of Tokushima
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- Himi Tetsuo
- Sapporo Medical University
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- Hayashi Yoshio
- University of Tokushima School of Dentistry
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- Takeda Noriaki
- University of Tokushima
Bibliographic Information
- Other Title
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- ミクリッツ病３例の検討
- リンショウ ミクリッツビョウ 3レイ ノ ケントウ
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Abstract
We reported three cases of Mikuhcz's disease. Mikulicz's disease was diagnosed by the following criteria: 1) symmetrical enlargement of the lacrimal and salivary glands lasting at least 3 months', 2) the lacrimal and salivary glands were microscopically involved in the infiltration of inflammatory cells, 3) sarcoidosis and other lymphoproliferative diseases were excluded. Three patients with Mikulicz's disease were all characterized by elevated IgG4 concentration in the serum and prominent infiltration of IgG4-positive plasmacytes in the minor salivary glands. On the contrary, there were no findings indicating sicca syndrome or anti-SS-A and SS-B antibodies, which characterize Sjögren syndrome. It is suggested that Mikulicz's disease is an IgG4-related plasmacytec disease, with a pathogenesis differing from that of Sjögren syndrome.
Journal
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- Practica Oto-Rhino-Laryngologica
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Practica Oto-Rhino-Laryngologica 101 (8), 591-597, 2008
The Society of Practical Otolaryngology
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Details 詳細情報について
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- CRID
- 1390001204263350656
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- NII Article ID
- 10021940832
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- NII Book ID
- AN00107089
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- ISSN
- 18844545
- 00326313
- http://id.crossref.org/issn/00326313
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- NDL BIB ID
- 9594091
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed