メニエール病 : ストレスと水代謝との関連で Meniere's Disease and Stress : An Involvement of the Vasopressin-aquaporin2 System in the Inner Ear

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Recently, there has been considerable evidence suggesting the hormonal control of the inner ear. The vasopressin-aquaporin2 (VP-AQP2) system may play an important role in the regulation of water in the inner ear. Endolymphatic hydrops, over-accumulation of endolymph, is thought to result from the malregulation of the VP-AQP2 system in inner ear fluid. We reported that plasma VP (p-VP) levels were elevated in Ménière's disease and that elevation was noted in cases of Ménière's disease with emotional or physical stress. Since stress is well-known to lead to excessive secretion of VP, it is likely that a stress-associated rise in p-VP causes a disturbance of the VP-AQP2 system in the inner ear, resulting in vertiginous attacks and/or aggravation of hearing in Ménière's disease. This paper reviews the clinical and experimental evidence supporting the novel view that endolymphatic hydrops, the morphological characteristics of Ménière's disease, reflects the mal-regulation of the VP-AQP2 system in inner ear fluid, and that a stress-associated rise in p-VP is one of the causative factors of vertigo and deafness in Ménière's disease.

収録刊行物

  • 耳鼻咽喉科臨床  

    耳鼻咽喉科臨床 101(9), 645-651, 2008-09-01 

    The Society of Practical Otolaryngology

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各種コード

  • NII論文ID(NAID)
    10021940989
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00326313
  • NDL 記事登録ID
    9635688
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-421
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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