書誌事項
- タイトル別名
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- Meniere's Disease and Stress-An Involvement of the Vasopressin-aquaporin2 System in the Inner Ear-
- メニエールビョウ ストレス ト ミズ タイシャ トノ カンレン デ
- An Involvement of the Vasopressin-aquaporin2 System in the Inner Ear
- ストレスと水代謝との関連で
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抄録
Recently, there has been considerable evidence suggesting the hormonal control of the inner ear. The vasopressin-aquaporin2 (VP-AQP2) system may play an important role in the regulation of water in the inner ear. Endolymphatic hydrops, over-accumulation of endolymph, is thought to result from the malregulation of the VP-AQP2 system in inner ear fluid. We reported that plasma VP (p-VP) levels were elevated in Ménière's disease and that elevation was noted in cases of Ménière's disease with emotional or physical stress. Since stress is well-known to lead to excessive secretion of VP, it is likely that a stress-associated rise in p-VP causes a disturbance of the VP-AQP2 system in the inner ear, resulting in vertiginous attacks and/or aggravation of hearing in Ménière's disease. This paper reviews the clinical and experimental evidence supporting the novel view that endolymphatic hydrops, the morphological characteristics of Ménière's disease, reflects the mal-regulation of the VP-AQP2 system in inner ear fluid, and that a stress-associated rise in p-VP is one of the causative factors of vertigo and deafness in Ménière's disease.
収録刊行物
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- 耳鼻咽喉科臨床
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耳鼻咽喉科臨床 101 (9), 645-651, 2008
耳鼻咽喉科臨床学会
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詳細情報 詳細情報について
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- CRID
- 1390282679239783168
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- NII論文ID
- 10021940989
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- NII書誌ID
- AN00107089
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- ISSN
- 18844545
- 00326313
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- NDL書誌ID
- 9635688
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
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