CHOLANGIOLOCELLULAR CARCINOMA PRESENTED WITH A LARGE HEPATIC TUMOR IN A YOUNG PATIENT-REPORT OF A CASE-

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  • 若年者に巨大肝腫瘍として発症した細胆管細胞癌の１例

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Abstract

A 25-year-old woman was referred to our hospital under a diagnosis of a large hepatic tumor detected by abdominal ultrasonography at a previous clinic. Laboratory examinations revealed HBs-Ag and HCV-Ab negative, mild liver dysfunction, mild inflammatory finding and tumor markers in normal ranges. Abdominal CT scan showed a large hepatic tumor in the right lobe of the liver which had two components of solid and cystic parts. The solid part of the tumor was enhanced in the early phase and the enhancement effect disappeared in the late phase, which was similar to hepato cellular carcinoma (HCC). The peripheral region of the cystic part was slightly enhanced, but its central region was not enhanced at all. Angiography showed irregular tumor stain. Therefore we diagnosed the tumor as malignant hepatic tumor, and performed right lobectomy of the liver. Macroscopically cut surface of the resected specimen included solid and cystic components, in which cholangiole cell-like tumor cells formed small glandular lumens histologically. Immunohistochemical staining of cytokeratin 7 was positive and hepatocyte negative. Consequently the tumor was diagnosed as cholangiolocellular carcinoma. The patient was discharged from the hospital on the 17th day after the operation. There have been no recurrence as of four years after the operation without any adjuvant therapy.

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