虚血性脳卒中患者におけるメタボリックシンドロームと大動脈弓部粥腫の関連 The association between metabolic syndrome and aortic arch atherosclerotic plaque in patients with acute ischemic stroke

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著者

    • 伊藤 敦史 ITO Atsushi
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center
    • 横田 千晶 YOKOTA Chiaki
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center
    • 豊田 一則 TOYODA Kazunori
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center
    • 永沢 光 NAGASAWA Hikaru
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center
    • 吉村 壮平 YOSHIMURA Sohei
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center
    • 大坪 亮一 OTSUBO Ryoichi
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center
    • 峰松 一夫 MINEMATSU Kazuo
    • 国立循環器病センター 内科脳血管部門 Cerebrovascular Division, Department of Medicine, National Cardiovascular Center

抄録

<i>Background and Purpose</i> : Metabolic syndrome (MetS) is associated with an increased risk of ischemic stroke. and aortic arch atherosclerotic plaque S4 mm in thickness (AAP) is also associated with ischemic stroke. but the relationship between MetS and AAP is unclear. We investigated this relationship and its impact on ischemic stroke recurrence.<br><i>Methods</i> : In 475 patients admitted because of acute ischemic stroke during the past two years. we examined 151 patients who wereexamined by transesophageal echocardiography (TEE) and for whom ail data were aailable. We followed up the patients and investigated the relationship between MetS snd ischemic stroke recurrence.<br><i>Results</i> :AAP was found in 47 patients (31.1%). Multiple logistic regression analysis showed that age and MetS were associated with AAP (age:OR1.07 : 1.02-1.11, p = 0.003, MetS:0R3.11 : 1.44-6.74, p = 0.004) in analysis excluding DM (model 1), and that only age was associated with AAP (OR1.05 : 1.01-1.10, p = 0.004)in analysis exeluding MetS (model 2). During a mean follow-up period of 401 days. there were 19 (12.6%) ischemic stroke recurrences. The Cox proportional hazards regression model showed that only AAP was associated with recurrence (OR2.90 : 1. 16-7.28,0 = 0.023).<br><i>Conclusions</i> : MetS was associated with AAP in patients with acute ischemic stroke. and conventional risk factors other than aging were not associated. AAP was associated with ischemic stroke recurrence. but MetS was not.

収録刊行物

  • 神経超音波医学 = Neurosonology : official journal of Japan Academy of Neurosonology  

    神経超音波医学 = Neurosonology : official journal of Japan Academy of Neurosonology 20(2), 119-123, 2007-12-30 

    The Japan Academy of Neurosonology

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