A Case Report of a Patient with Small Bowel Adenocarcinoma Undergoing Combination Therapies with Chemotherapy and Phototherapy

• GOTO Shigeru

  Iwao Hospital

• IWAO Yujirou

  Iwao Hospital

• IWAO Junichiro

  Iwao Hospital

• TOHARA Kazuhide

  Department of Surgery, NishiBeppu Hospital

• KITANO Seigo

  Department of Surgery I, Oita Medical University

Bibliographic Information

Other Title

• 癌化学療法の相補療法として光線が有効であったと思われる小腸癌の１症例
• ガン カガク リョウホウ ノ ソウホ リョウホウ ト シテ コウセン ガ ユウコウ デ アッタ ト オモワレル ショウチョウ ガン ノ 1 ショウレイ

Abstract

A case report<br>A 70-year-old male with small bowel adenocarcinoma involving retroperitoneal invasion had undergone chemotherapy after non-curative operation. However, this patient had to discontinue the first and second lines of chemotherapies within one month due to serious side effects of anti-cancer agents. Subsequently, the patient complained of severe low-back pain and there was evidence of local recurrence around the resected small intestine. Therefore, phototherapy was applied three times a week to relieve the low-back pain while the patient underwent the third line of chemotherapy. It was interesting to note that these combination therapies coincidentally ameliorated the various side effects caused by anti-cancer drugs. For one year during the third line of chemotherapy, the patient had to temporarily discontinue chemotherapy only two times when phototherapy was not available for one week due to consecutive national holidays in May and November. The quality of life of this patient was well maintained, and he only needed to be hospitalized for the last two months before he died.<br>Epidemiological studies have shown a high incidence of cancer in people less exposed to solar rays. The sunshine “vitamin” 1 alpha, 25-dihydroxy vitamin D₃ (1, 25(OH)₂D₃) is involved in these epidemiological studies based on the evidence that 1, 25(OH)₂D₃ is an antiproliferative agent that may inhibit proliferation of cancer cells in vitro and development in animals. To elucidate the synergetic effect of phototherapy in combination with chemotherapy, we assayed serum levels of 1, 25(OH)₂D₃ in this patient compared with those of end-stage cancer patients undergoing chemotherapy alone. Serum levels of 1, 25(OH)₂D₃ in this patient after receiving the combination therapies were higher than those in other cancer patients treated with chemotherapy alone.<br>Our results indicate that phototherapy may be a good complementary therapy with chemotherapy for cancer patients.

Journal

• The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine

  The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 71 (4), 221-228, 2008

  The Japanese Society of Balneology, Climatology and Physical Medicine

Keywords

• phototherapy
• chemotherapy
• 1 alpha
• 25-dihydroxy vitamin D₃(1,25(OH)₂D₃)
• small bowel adenocarcinoma

Details

• CRID: 1390001206569739648
• NII Article ID: 10021950409
• NII Book ID: AN00186245
• DOI: 10.11390/onki1962.71.221
• ISSN: 18843697
• ISSN: 00290343
• NDL BIB ID: 9631579
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9631579
• Web Site: https://search.jamas.or.jp/link/ui/2008333713
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed