ハンセン病動物モデルの歴史と高血圧ヌードラットの特徴

• 與儀 ヤス子

  前国立感染症研究所ハンセン病研究センター生体防御部

• 藤村 響男

  北里大学 (医) 皮膚科学講座

• 鈴木 幸一

  国立感染症研究所ハンセン病研究センター生体防御部

書誌事項

タイトル別名

• History for animal model of Hansen's disease and characteristic of leprosy in hypertensive nude rat

抄録

The long search of an animal model for leprosy were carried out as many researchers since the Mycobacterium leprae discovery by Dr. Hansen in 1874. The remarkable results were left after the development of the foot-pad method by Dr. Shepard in 1960. The introduction of the T-R mouse and athymic (nude) mouse for leprosy research, alsospontaneity examples of Hansen's disease was reported to armadillo, chimpanzee and mangabay monkey, and it was confirmed that Hansen's disease was the zoonosis. Although, We have established a congenic hypertensive nude rat, SHR/NCrj-rnu (SHR.F344-Foxn1^rnu), carrying nude (rnu) and hypertension genes. SHR/NCrj-rnu rats obtained showed high susceptibility to M. leprae and showed a characteristic disease with a progressive pattern of leproma formation. Also this hypertensive nude rat strain produce high level of IL-10. Therefore, congenic hypertensive nude rat may be useful for an animal model to leprosy.

収録刊行物

• 日本ハンセン病学会雑誌

  日本ハンセン病学会雑誌 77 (3), 197-204, 2008

  日本ハンセン病学会

キーワード

• 高血圧ヌードラット
• 動物モデル
• ハンセン病
• らい腫らい

詳細情報

• CRID: 1390282681298248832
• NII論文ID: 10021952354
• NII書誌ID: AN10559906
• DOI: 10.5025/hansen.77.197
• ISSN: 1884314X
• ISSN: 13423681
• PubMed: 18800640
• Web Site: https://search.jamas.or.jp/link/ui/2008306959
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可