結核菌のマクロファージ内生存機構

• 河村 伊久雄

  京都大学大学院医学研究科微生物感染症学

書誌事項

タイトル別名

• Advances in understanding of the virulence mechanism of Mycobacterium tuberculosis

抄録

Mycobacterium tuberculosis (MTB) is an intracellular pathogen that has evolved strategies to enable growth in macrophages. The bacterium is able to inhibit fusion of phagosomes with lysosomes through secretion of some bacterial components and modulation of host intracellular signaling pathways. Furthermore, it has been shown that phagositosed MTB is killed within macrophages after treatment with IFN-γ in vitro. However, virulent MTB is capable of surviving in macrophages in vivo and persists in host even after acquired immunity has developed. These data suggest that MTB has developed a sophisticated immune evasion mechanism. In this issue, the strategies of MTB for intracellular survival and immune evasion, which have been unraveled so far, are shown and the mechanisms are discussed.

収録刊行物

• 日本ハンセン病学会雑誌

  日本ハンセン病学会雑誌 77 (3), 219-224, 2008

  日本ハンセン病学会

キーワード

• アポトーシス
• オートファジー
• 結核菌
• ファゴソーム
• マクロファージ

詳細情報

• CRID: 1390001206321523968
• NII論文ID: 10021952398
• NII書誌ID: AN10559906
• DOI: 10.5025/hansen.77.219
• ISSN: 1884314X
• ISSN: 13423681
• PubMed: 18800644
• Web Site: https://search.jamas.or.jp/link/ui/2008306962
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可