結核菌のマクロファージ内生存機構 Advances in understanding of the virulence mechanism of Mycobacterium tuberculosis
<i>Mycobacterium tuberculosis</i> (MTB) is an intracellular pathogen that has evolved strategies to enable growth in macrophages. The bacterium is able to inhibit fusion of phagosomes with lysosomes through secretion of some bacterial components and modulation of host intracellular signaling pathways. Furthermore, it has been shown that phagositosed MTB is killed within macrophages after treatment with IFN-γ in vitro. However, virulent MTB is capable of surviving in macrophages in vivo and persists in host even after acquired immunity has developed. These data suggest that MTB has developed a sophisticated immune evasion mechanism. In this issue, the strategies of MTB for intracellular survival and immune evasion, which have been unraveled so far, are shown and the mechanisms are discussed.
- 日本ハンセン病学会雑誌 = Japanese journal of leprosy
日本ハンセン病学会雑誌 = Japanese journal of leprosy 77(3), 219-224, 2008-09-01
Japanese Leprosy Association