結核菌のマクロファージ内生存機構 Advances in understanding of the virulence mechanism of Mycobacterium tuberculosis

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著者

    • 河村 伊久雄 KAWAMURA Ikuo
    • 京都大学大学院医学研究科微生物感染症学 Department of Microbiology, Kyoto University Graduate School of Medicine

抄録

<i>Mycobacterium tuberculosis</i> (MTB) is an intracellular pathogen that has evolved strategies to enable growth in macrophages. The bacterium is able to inhibit fusion of phagosomes with lysosomes through secretion of some bacterial components and modulation of host intracellular signaling pathways. Furthermore, it has been shown that phagositosed MTB is killed within macrophages after treatment with IFN-γ in vitro. However, virulent MTB is capable of surviving in macrophages in vivo and persists in host even after acquired immunity has developed. These data suggest that MTB has developed a sophisticated immune evasion mechanism. In this issue, the strategies of MTB for intracellular survival and immune evasion, which have been unraveled so far, are shown and the mechanisms are discussed.

収録刊行物

  • 日本ハンセン病学会雑誌 = Japanese journal of leprosy  

    日本ハンセン病学会雑誌 = Japanese journal of leprosy 77(3), 219-224, 2008-09-01 

    Japanese Leprosy Association

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各種コード

  • NII論文ID(NAID)
    10021952398
  • NII書誌ID(NCID)
    AN10559906
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    13423681
  • データ提供元
    CJP書誌  J-STAGE 
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