Clinical significance of platelet activation ratio, plasma interleukin-18 and high sensitivity C-reactive protein in patients with sleep apnea syndrome

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  • OKADA Yasutaka
    The Nippon Dental University, Graduate School at Niigata, Course of Clinical Stomatology, Oral and Maxillofacial Surgery and Systemic Medicine
  • HIROYASU Kazuhiko
    The Nippon Dental University Niig ata Hoshital, Oral and Maxillofacial Surgery
  • SHIBASAKI Koichi
    The Nippon Dental University, Graduate School at Niigata, Course of Clinical Stomatology, Oral and Maxillofacial Surgery and Systemic Medicine

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  • 睡眠時無呼吸症候群患者における活性化血小板比率と血中インターロイキン‐１８，高感度ＣＲＰ測定の臨床的意義
  • スイミンジ ムコキュウ ショウコウグン カンジャ ニ オケル カッセイカ ケッショウバン ヒリツ ト ケッチュウ インターロイキン 18 コウカンド CRP ソクテイ ノ リンショウテキ イギ

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Abstract

Introduction: Hypoxia in sleep apnea syndrome (SAS) worsens arteriosclerosis, hypertension and vascular diseases. Disease severity of SAS is correlated with platelet function and various cytokines. To clarify the evidence, we analyzed the platelet activation, interleukin-18 (IL-18), and high sensitivity C-reactive protein (hs-CRP) in SAS patients.<BR>Materials and Methods: Sixty-six patients were divided into four groups (non-SAS, SAS-mild, SAS-moderate and SAS-severe) with the apnea-hypopnea index (AHI). Platelet activation was examined by CD62P positive platelets analyzed by flow cytometry. Plasma levels of IL-18 and hs-CRP were measured by ELISA and Behring Nepherometer II in each patient.<BR>Results: Activated platelet ratio in PRP showed a hight endency in SAS-moderate and SAS-severe, as compared with the non-SAS group. Plasma level of IL-18 was significantly high in SAS-severe, as compared with the non-SAS group.<BR>Conclusion: In the SAS patients, activated plateletratio in PRP and plasma level of IL-18 was useful as an index reflecting the disease severity of SAS. However, there were no significant differences between activated platelet ratio in whole blood, hs-CRP level and the disease severity of SAS.

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