Surface Modification Enhances Osteoblast Behavior and Bone Formation on Thin Hydroxyapatite Layers Deposited Using a Novel Anodization-Hydrothermal Treatment on Commercially Pure Titanium Endosseous Implants

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著者

    • TAKEBE Jun
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University
    • NAKASATO Yoshihiro
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University
    • ITO Shigeki
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University
    • KIKUCHI Seiichiro
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University
    • ITOH Sozo
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University
    • SHIOYAMA Tsukasa
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University
    • ISHIBASHI Kanji
    • Department of Fixed Prosthodontics, School of Dentistry, Iwate Medical University

抄録

In the present study, we assessed the effects of commercially pure titanium (cpTi) by anodic oxidation and hydrothermal treatment (SA-treated cpTi) on osteoblastic differentiation and interfacial bone formation through parallel in vitro and in vivo investigations. Osteoblast cells were cultured on SA-treated cpTi disks for 5, 7, 10, and 14 days. Bone matrix mineralization was assessed by EPMA. The levels of collagen I, alkaline phosphatase, osteocalcin, osteopontin, bone sialoprotein, and β-actin mRNA were analyzed using RT-PCR. In addition, SA-treated cpTi implants were placed in the mandibles of beagles for 14 days, and then examined histologically by light microscopy. Widespread Ca and P signals were observed early in the in vitro culturing period, and mRNA expression was up-regulated in cells that were in contact with the SA-treated cpTi. The bone-to-implant contact formed at the mandible SA-treated cpTi implant sites involved direct contact of the implant with the surrounding bone tissue. These results demonstrate the potential of SA-treated cpTi surfaces for enhancing surface-specific expression of osteoblastic phenotypes and for inducing changes in bone matrix gene expression.

収録刊行物

  • Prosthodontic research & practice  

    Prosthodontic research & practice 7(2), 159-161, 2008-07-01 

    Japan Prosthodontic Society

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各種コード

  • NII論文ID(NAID)
    10021955128
  • NII書誌ID(NCID)
    AA11728086
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13477021
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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