Application of Anti-Microbial Protein Lysozyme for Dental Materials
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There are the problems of harmful side effect such as allergy and durability of antibacterial effect at the dental materials. The purpose of this study is to develop the dental materials which can solve these problems. And we focus on the anti-microbial proteins, lysozyme (LYZ) which exists in oral cavity commonly. In this study the development of anti-microbial dental cement containing the cation exchange resin which binds anti-microbial protein LYZ was performed. The amount of LYZ binding to the glass ionomer cement and its anti-microbial activity against Streptococcus mutans (S.mutans) were examined. Then the mechanical property of the glass ionomer cement-containing the cation exchange resin was tested. The result presented that the amount of LYZ binding to the cement containing the cation exchange resin was significantly greater than the cement non-containing the cation exchange resin (p<0.05). Moreover, the cement binding with LYZ showed anti-microbial activity against S.mutans. In compression strength test, the strength of cement containing cation exchange resin (3wt%) was lower than cement non-containing cation exchange resin (p<0.05). The findings suggest that glass ionomer cement-containing cation exchange resin binds LYZ and have an anti-microbial activity against S.mutans. After all, the application of cation exchange resin for prosthesis is useful for prevention of dental caries and treatment for the other oral diseases, since the concentration of anti-microbial protein in saliva may increase in oral cavity by this procedure.
- Prosthodont Res. Pract.
Prosthodont Res. Pract. 7(2), 225-227, 2008-07-01
Japan Prosthodontic Society