Organic Cation Transporters and their Pharmacokinetic and Pharmacodynamic Consequences
-
- CHOI Min-Koo
- Department of Pharmaceutics, College of Pharmacy, Seoul National University
-
- SONG Im-Sook
- Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine
Search this article
Abstract
To clarify the considerable interindividual variability in the pharmacokinetics, efficacy, and toxicity of drugs, genetic polymorphism of drug transporters has attracted interest because these transporters play important roles in the gastrointestinal absorption, biliary and renal elimination, and distribution to target sites of their substrates. Of the over 325 members of the solute carrier superfamily, this review focuses on the molecular features, expressional regulation, and genetic polymorphisms of the organic cation transporter (OCT) family, and the pharmacokinetic or pharmacodynamic consequences for organic cationic drugs. Although the clinical significance is still unclear, many studies have reported the importance of OCTs in the tissue distribution and elimination of their substrates in vitro and in vivo, and the impact of functional non-synonymous single nucleotide polymorphisms or differential expression levels of OCTs on the large interindividual variation in the pharmacokinetics and response of organic cationic drugs such as metformin, imatinib, and cisplatin.<br>
Journal
-
- Drug Metabolism and Pharmacokinetics
-
Drug Metabolism and Pharmacokinetics 23 (4), 243-253, 2008
The Japanese Society for the Study of Xenobiotics
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282680157781760
-
- NII Article ID
- 10021956185
-
- NII Book ID
- AA1162652X
-
- ISSN
- 18800920
- 13474367
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed