Adsorption and delivery of cage-shaped protein with nanoparticle, ferritin, onto a silicon substrate

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  • 球殻状たんぱく質フェリチンの固体表面吸着のナノ制御
  • キュウカクジョウ タンパクシツ フェリチン ノ コタイ ヒョウメン キュウチャク ノ ナノ セイギョ

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Abstract

<p>A new process for fabricating functional structures using protein supramolecules, which was named the Bio-Nano-Process (BNP), was proposed. One of the most important features of the BNP is the placement or alignment of cage-shaped proteins, ferritins, which have nanoparticles (NPs) synthesized in their cavities, onto the designated areas or positions. The precise control of electrostatic interaction among proteins, substrates and patterns with modified surfaces makes it possible to fabricate a ferritin monolayer with high density and single ferritin placement. Carbonaceous-material-binding peptides attached to the outer surface of ferritin can be used to fabricate a two-dimensional hexagonally close-packed ferritin array on a wide surface area of a silicon substrate, and titanium-binding peptides can be used to produce a two-dimensional hexagonally close-packed ferritin array on a hexagonal titanium pattern. The bifunctionality of the titanium-binding peptides, recognition and biomineralization, can be used to produce a three-dimensional ferritin multilayer in a layer-by-layer manner.</p>

Journal

  • Oyo Buturi

    Oyo Buturi 77 (10), 1199-1205, 2008-10-10

    The Japan Society of Applied Physics

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