Effects of Intravenous Arginine Administration on Cerebral Circulation in the Rat

この論文にアクセスする

この論文をさがす

著者

    • 野川 茂 NOGAWA Shigeru
    • Department of Neuroloev, School of Medicine, Keio University Department of Neurology, School of Medicine, Keio University

抄録

The present study was designed to determine the effects of intravenous infusion of L-arginine (ARG), an endogenous precursor of nitric oxide (NO), on the cerebral circulation in the rat. Systemic arterial blood pressure (ABP) was continuously recorded, and local cerebral blood flow (LCBF) was measured by the iodo[<sup>14</sup>C]antipyrine method at a point of time as follows: In Saline group (n=12); at 3min after an intravenous injection of saline. In N<sup>G</sup>-monomethyl-L-arginine (L-NMMA) group (n=7); at 3min after an injection of L-NMMA (30mg/kg/30 see). In L-NMMA+L-ARG group (n=7); at 3min after an infusion of L-ARG free base (300mg/kg/1min) 3min after prior injection of L-NMMA (30mg/kg/ 30 sec). In L-ARG-1 group (n=7); during an infusion of L-ARG free base (300mg/kg/1min). In L-ARG-2 group (n=8); at 3min after an administration of L-ARG free base (300mg/kg/1min). In D-ARG group (n=5); at 3min after an infusion of D-ARG free base (300mg/kg/1min). (1) The diffuse reduction in LCBF and increase in ABP induced by L-NMMA were almost completely reversed by excess L-ARG. (2) During the administration of L-ARG, a sustained decrease in ABP was observed, but LCBF revealed no significant change. (3) At 3min after the infusion of L-ARG, LCBF was significantly decreased in several regions, while ABP recovered. (4) The infusion of D-ARG also induced a transient decrease in ABP, but did not alter LCBF. The effect of L-ARG on ABP may not be entirely due to an increase in substrate availability for NO synthase, since the D-enantiomer also had some vasodilatory property. Regarding the therapeutic application of L-ARG, further investigations on its actions should be performed under various conditions.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 44(1), 19-29, 1995-03-01 

    The Keio Journal of Medicine

参考文献:  59件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

被引用文献:  1件

被引用文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10021984745
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00229717
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ