Recent Progress in Studies on Autoantigens for Various Autoimmune Blistering Skin Diseases

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著者

    • 橋本 隆 HASHIMOTO Takashi
    • Denartment of Dermatoloev. School of Medicine. Keio University Department of Dermatology, School of Medicine, Keio University

抄録

Autoimmune blistering skin diseases develop separation either between epidermal keratinocytes or dermo-epidermal junction. Recent studies have revealed that the autoantigens for these diseases are components of either the desmosome, the cell adhesion junction between keratinocytes, or the hemidesmosome complex, cell adhesion machinery at the dermo-epidermal junction. Thus, the major pemphigus antigens are desmogleins, one of desmosomal cadherins. Both the 230 kD and 180 kD bullous pemphigoid antigens are present in the hemidesmosome, and epidermal basement membrane zone-specific extracellular matrices, epiligrin and type VII collagen, are detected by sera of cicatricial pemphigoid and epidermolysis bullosa acquisita, respectively. Furthermore, animal model studies using newborn mice have revealed that these autoantibodies are really pathogenic and can induce blister formation by passive transfer into mice. Therefore, these skin diseases seem to be a typical model for various autoimmune diseases, for most of which the role of autoantibodies has not yet been revealed.

収録刊行物

  • Keio journal of medicine

    Keio journal of medicine 44(4), 115-123, 1995-12-01

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021985090
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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