Molecular Basis of Embryo Implantation
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Implantation following placentation is a unique system for mammals to reproduce. The initial attachment of the embryo to the uterus occurs <i>via</i> the apical cell membranes of two epithelial cells, trophoblast of the blastocyst and surface epithelial cells of the endometrium. Analysis of the implantation at the molecular level has been a difficult problem in reproductive biology. Recently, a major break through was made in this area: A discovery of a novel cell adhesion molecule complex mediating the initial attachment of trophoblast to the endometrial epithelium.<sup>1</sup> This review provides a brief overview of cell adhesion molecules involved in implantation and introduces identification and characterization of trophinin and tastin.
- Keio J. Med.
Keio J. Med. 45(1), 37-43, 1996-03-01
The Keio Journal of Medicine