Modulation of Elastin Expression and Cell Proliferation in Vascular Smooth Muscle Cells in vitro

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著者

    • 多島 新吾 TAJIMA Shingo
    • Department of Dermatology, School of Medicine, Keio University Department of Dermatology, School of Medicine, Keio University

抄録

Elastin expression in cultured vascular smooth muscle cell (VSMC) was found to be enhanced by potent inhibitors of VSMC proliferation including minoxidil, heparin and retinoic acid. By contrast, elastin expression was declined by potent stimulators of VSMC proliferation like epidermal growth factor, high K<sup>+</sup>, angiotension II and phorbol ester. To elucidate the relationship between elastin expression and cell proliferation, the elastin expression in the different cell growth states brought by cell-synchronizing culture or suspension culture, a culture system independent of potent modulators of VSMC proliferation. Elastin was found to be expressed maximally at G0 and minimally at G2/M phases, suggesting that cell growth state regulates elastin expression in VSMC culture. Synthetic elastin peptide VPGVG or its polymeric form (VPGVG)n enhanced VSMC proliferation, which resulted in the reduction of elastin expression. The results suggests that elastin fragment regulates VSMC proliferation. These correlation between elastin expression and cell growth state may play an essential role in elastin metabolism under the normal and diseased conditions.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(1), 58-62, 1996-03-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021985746
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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