Beyond Oxidized LDL : The Initiation and Progression of Atherosclerosis

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著者

    • 広瀬 信義 HIROSE Nobuyoshi
    • Department of Geriatric Medicine, School of Medicine, Keio University Department of Geriatric Medicine, School of Medicine, Keio University
    • 新井 康通 ARAI Yasumichi
    • Department of Geriatric Medicine, School of Medicine, Keio University Department of Geriatric Medicine, School of Medicine, Keio University
    • 川村 昌嗣 KAWAMURA Masahide
    • Department of Geriatric Medicine, School of Medicine, Keio University Department of Geriatric Medicine, School of Medicine, Keio University
    • 重松 洋 SHIGEMATU Hiroshi
    • Department of Geriatric Medicine, School of Medicine, Keio University Department of Geriatric Medicine, School of Medicine, Keio University

抄録

Oxidized-low density lipoprotein (ox-LDL) exhibits various atherogenic properties, such as the formation of foam cells, the recruitment of macrophages into arteries, the promotion of cell growth, the formation of thrombi, and the development of vasoconstriction. Antioxidants inhibit atherosclerosis in cholesterol-fed animals by preventing the recruitment of macrophages into the arteries suggesting that oxidation is important for such recruitment of macrophages, and that it is responsible for early development of atherosclerosis. Calcification and an increase in extracellular matrix (ECM) are frequently observed in advanced atherosclerosis. These processes are active and regulated, not passive and degenerative, and do not appear to be controlled by ox-LDL. The control of calcifications and ECM increase will provide new directions in the treatment of atherosclerosis especially in the advanced stages. Future treatment should include strategies to inhibit the calcification and the increase in ECM.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(2), 90-94, 1996-06-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021985875
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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