Current Topics in Neuroleptic-induced Extrapyramidal Symptoms in Japan

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著者

    • 稲田 俊也 INADA Toshiya
    • National Institute of Mental Health, National Center of Neurology and Psychiatry National Institute of Mental Health, National Center of Neurology and Psychiatry
    • 八木 剛平 YAGI Gohei
    • Department of Neuropsychiatry, School of Medicine, Keio University Department of Neuropsychiatry, School of Medicine, Keio University

抄録

This article reviews current topics in neuroleptic-induced extrapyramidal symptoms in Japan, focusing especially on the clinical features of akathisia and dystonia. Akathisia is a common side effect associated with antipsychotic drugs. It is most commonly characterized by subjective inner restlessness and objective motor signs, especially in the lower extremities. The mechanisms underlying akathisia remain unclear and controversial; however, an increase in the activity of β-adrenergic systems relative to dopaminergic systems has been hypothesized, based on clinical therapeutic observations that β-blocking agents are effective in this condition. A Japanese version of the Barnes Akathisia Scale has recently been established and uses a standardized videotape method for its precise evaluation. Various acute and chronic manifestations of neuroleptic-induced dystonia have been reported in Japan, including blepharospasm, difficulty in opening the eye lids, torticollis, retrocollis, oculogyric crisis, and Pisa syndrome. This review also introduces several other topics related to drug-induced extrapyramidal symptoms in Japan. These include; 1) the Drug-Induced Extra-Pyramidal Symptoms Scale (DIEPSS), which has recently been established, 2) studies on the discontinuation of anticholinergic drugs, and 3) a summary of extrapyramidal symptoms induced by drugs other than neuroleptics.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(2), 95-99, 1996-06-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021985902
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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