CD7 Positive Acute Lymphoblastic Leukemia Successfully Treated with High Dose Cytosine Arabinoside and Mitoxantrone : A Case Report

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著者

    • 中島 秀明 NAKAJIMA Hideaki
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University
    • 木崎 昌弘 KIZAKI Masahiro
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University
    • 川合 陽子 KAWAI Yohko
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University
    • 石田 明 ISHIDA Akaru
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University
    • 得平 道英 TOKUHIRA Michihide
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University
    • 渡辺 清明 WATANABE Kiyoaki
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University
    • 池田 康夫 IKEDA Yasuo
    • Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University Divisioin of Hematology, Department of Internal Medicine and Laboratory Medicine, School of Medicine, Keio University

抄録

A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and 1-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(2), 114-117, 1996-06-01 

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10021986027
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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