Interleukin-1 in Cerebral Ischemia

この論文にアクセスする

この論文をさがす

著者

    • BETZ A Lorris
    • Department of Surgery (Neurosurgery), University of Michigan
    • SCHIELKE Gerald P
    • Department of Neurological and Neurodegenerative Diseases, Parke-Davis Pharmaceutical Research, Division of the Warner-Lambert Company
    • YANG Guo-Yuan
    • Department of Surgery (Neurosurgery), University of Michigan

抄録

During the past several years, it has become increasingly apparent that interleukin-1 (IL-1), particularly IL-1β plays an important role in brain injury during ischemia. Studies from various laboratories have shown that IL-1β mRNA and IL-1β protein are synthesized early in ischemia and that the injection of IL-1β into ischemic brain enhances edema formation. The most direct evidence that IL-1β contributes to ischemic injury, however, is the demonstration that infarct volume in focal ischemia is reduced following intraventricular injection of an endogenous interleukin-1 receptor antagonist (IL-1ra), or after IL-lra is overexpressed in brain using an adenoviral vector to transfer IL-Ira cDNA to brain cells. Ischemic injury is also reduced in mice that fail to produce IL-1β because of an abnormal interleukin-1β converting enzyme gene (ICE knockout mice). At the present time, it is unclear how IL-1β causes brain injury, but several possible mechanisms include 1) stimulation of an inflammatory response through the activation of glia or the induction of other cytokines and/or endothelial adhesion molecules and 2) release of free radicals through stimulation of arachidonic acid metabolism and/or nitric oxide synthase activity.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(3), 230-238, 1996-09-01 

    The Keio Journal of Medicine

参考文献:  102件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10021986654
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ