Signaling Molecules and Neuroglial Activation in the Injured Central Nervous System.

• Raivich Gennadij

  Department of Neuromorphology, Max-Planck Institute of Psychiatry

• Bluethmann Horst

  Pharma Research Gene Technologies

• Kreutzberg Georg W

  Department of Neuromorphology, Max-Planck Institute of Psychiatry

抄録

Injury of the central nervous system leads to a highly reproducible activation of neurons, astrocytes and microglia, which plays an important role in the posttraumatic repair of the damaged neural tissue. Recent work on proinflammatory cytokines has begun to shed light on the molecular mechanisms that direct and control this repair process. Here we summarize data on the regulation of these cytokines, which led to the identification of the macrophage colony-stimulating factor and interleukin-6 as key factors in microglial and astrocyte activation.

収録刊行物

• Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ

  Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ 45 (3), 239-247, 1996

  The Keio Journal of Medicine

キーワード

• cytokines
• IL-6
• MCSF
• microglia
• astrocyte

詳細情報

• CRID: 1390282681314970496
• NII論文ID: 10021986757
• NII書誌ID: AA00710216
• DOI: 10.2302/kjm.45.239
• ISSN: 18801293
• ISSN: 00229717
• PubMed: 8897767
• Web Site: https://www.jstage.jst.go.jp/article/kjm1952/45/3/45_3_239/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997097616
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可