ICAM-1 as a Potential Target for Treatments Blocking the Host Response in Stroke.
-
- Lindsberg Perttu J
- Department of Neurology, University of Helsinki
Search this article
Abstract
Leukocytes and their actions have been implicated in the pathogenesis of microcirculatory and cytotoxic perturbations in experimental stroke models. Experiments in several models of stroke patho-physiology have demonstrated the important role of endothelial intercellular adhesion molecule (ICAM-1) in targeting the leukocyte response to the ischemic brain region and transmigration of polymorphonuclears into the parenchyma. In this article, investigations suggesting beneficial effects of anti-adhesion therapies blocking the endothelial ICAM-1 or its counter-receptor CD11/CD18 on leukocytes are reviewed. This evidence should be viewed also in the context of human stroke, which has also recently been shown to overexpress ICAM-1 molecules on the infarcted endothelium. Well-tolerated monoclonal antibodies (mAb) blocking ICAM-1 might eventually be shown to possess therapeutic value acutely in clinical stroke victims, perhaps in combination with thrombolytic therapy.
Journal
-
- The Keio Journal of Medicine
-
The Keio Journal of Medicine 45 (3), 254-262, 1996
The Keio Journal of Medicine
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282681314966912
-
- NII Article ID
- 10021986902
-
- NII Book ID
- AA00710216
-
- ISSN
- 18801293
- 00229717
-
- PubMed
- 8897769
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed