Functional Implication of Secretory Proteases Derived from Microglia in the Central Nervous System

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著者

    • 高坂 新一 KOHSAKA Shinichi
    • Department of Neurochemistry, National Institute of Neuroscience Department of Neurochemistry, National Institute of Neuroscience
    • 浜之上 誠 HAMANOUE Makoto
    • Department of Neurochemistry, National Institute of Neuroscience Department of Neurochemistry, National Institute of Neuroscience

抄録

We have demonstrated that microglia produce certain secretory proteases which have been found to be important determinants of microglial properties, in surrounding cells and regenerative processes. In recent years, it has become clear that secretory proteases, particularly PGn-PA (plasminogen-plasminogen activator) system, work not only on catalysis of proteins in the extracellular space but also on cell growth, cell function, differentiation, proliferation and remodeling. These diverse effects may be derived from the unique structures of these enzymes, including their accesary domains. In particular, kringle domains have been shown to be important for interactions with other proteins. The results of these studies indicate that microglial secretory proteases participate to a great extent in physiological processes involving the regulation of neuronal growth, neuronal function and regenerative stages in the CNS.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(3), 263-269, 1996-09-01 

    The Keio Journal of Medicine

参考文献:  51件

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各種コード

  • NII論文ID(NAID)
    10021986942
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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