Pathology of Acquired Immunodeficiency Syndrome (AIDS) in Children

この論文にアクセスする

この論文をさがす

著者

    • JOSHI Vijay V
    • Department of Pathology and Laboratory Medicine, Hartford Hospital and Connecticut Children's Medical Center

抄録

Overview: Acquired Immunodeficiency Syndrome (AIDS) was first described to occur in children in 1983. With experience of increasing number of cases of AIDS, pathologic lesions in various organs and tissues such as lungs, brain, G.I. tract, heart, blood vessels, lymph nodes, spleen, bone marrow, etc. became evident in autopsy and biopsy specimens. These pathologic lesions were classified into four groups based on known or suspected pathogenesis: 1) Primary lesions due to Human Immunodeficiency (HIV) infection itself (lymph nodes, brain, etc), 2) associated lesions related to direct or indirect sequelae of HIV infection (Opportunistic infections, PLH/LIP complex, etc), 3) lesions of undetermined pathogenesis, (cardiomyopathy, arteriopathy, thrombocytopenia, nephropathy, etc), and 4) lesions of multifactorial pathogenesis (villous atrophy of intestine, thymic lesions, etc). Update: In recent years the emphasis of pathologic study is on the reactive and neoplastic proliferative disorders. These disorders include nodal and extranodal lymphoproliferative lesions (such as myoepithelial sialadenitis, malignant lymphomas, etc), smooth muscle tumors (SMTs), Kaposi's sarcoma, Human Papilloma virus associated genital lesions and miscellaneous tumors. In a recent study, it has been shown that Epstein-Barr virus (EBV) may be related to the pathogenesis of SMTs. The most recently recognized lymphoproliferative lesions include those of mucosa associated lymphoid tissue (MALT) of salivary glands, lungs and tonsils. The MALT lymphomas in children with AIDS are responsive to therapy and tend to take an indolent clinical course. Therefore recognition of MALT lymphomas as a distinctive lesion in pediatric AIDS is of practical importance. In view of increasing incidence of HIV and HPV infections in adolescent females seen in certain countries attention should also be focused on early detection of HPV related genital lesions so that their possible progression to intraepithelial and invasive cervical carcinoma can be prevented.

収録刊行物

  • Keio journal of medicine  

    Keio journal of medicine 45(4), 306-312, 1996-12-01 

    The Keio Journal of Medicine

参考文献:  34件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10021987164
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ