Neurotrophic Activity in Cytokine-activated Astrocytes.

• 吉田 一成

  Department of Neurosurgery, School of Medicine, Keio University

• 戸谷 重雄

  Department of Neurosurgery, School of Medicine, Keio University

抄録

Accumulating evidence indicates that various neurotrophic factors (NTFs) exist and function in the brain. In the mature mammalian brain, NTF expression is exclusively restricted to neurons. However, astrocytes activated by various cytokines, including fibroblast growth factor and interleukin-1β, produce a significant amount of nerve growth factor (NGF) in vitro. Furthermore, non-NGF type NTF expression in astrocytes is also activated by the cytokines. The cytokines also enhance both release of ciliary neurotrophic factor from and expression of high-molecular weight basic fibroblast growth factor (FGF) in astrocytes. In the early phase following brain injury, cytokine-activated astrocytes rescue the damaged neurons via NTFs and other biologically active molecules.

収録刊行物

• Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ

  Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ 46 (2), 55-60, 1997

  The Keio Journal of Medicine

キーワード

• astrocyte
• cytokine
• neurotrophic factor
• cell adhesion molecule

詳細情報

• CRID: 1390282681311737728
• NII論文ID: 10021987686
• NII書誌ID: AA00710216
• DOI: 10.2302/kjm.46.55
• ISSN: 18801293
• ISSN: 00229717
• PubMed: 9212587
• Web Site: https://www.jstage.jst.go.jp/article/kjm1952/46/2/46_2_55/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可