Disappearance of Serum Hepatitis C Virus RNA within Two Days after One Dose Interferon Administration is Predictive for Response to High-dose Interferon-.ALPHA.2b Treatment for Chronic Hepatitis C.
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- 斎藤 英胤
- 慶應インターフェロン-α2b研究会
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- 海老沼 浩利
- 慶應インターフェロン-α2b研究会
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- 厚川 和裕
- 慶應インターフェロン-α2b研究会
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- 高橋 正彦
- 慶應インターフェロン-α2b研究会
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- 増田 哲也
- 慶應インターフェロン-α2b研究会
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- 大石 温子
- Department of Internal Medicine, School of Medicine, Keio University
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- 野尻 治
- 慶應インターフェロン-α2b研究会
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- 水岡 慶二
- BML General Laboratory, Saitama
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- 石井 裕正
- Department of Internal Medicine, School of Medicine, Keio University
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抄録
We have reported the Keio multicenter randomized trial of interferon-a2b treatment for chronic hepatitis C, hypothesizing that disappearance of serum hepatitis C virus (HCV) ribonucleic acid (RNA) during the first 2 days by one dose administration of interferon is a predictive factor of final response to the high-dose interferon treatment. In this study we quantified HCV RNA by multicyclic reverse transcription-polymerase chain reaction in the stored sera of the same patients with our previous study. The multivariate analysis confirmed that the pretreatment HCV RNA levels and HCV genotype were significantly correlated with the response to the 6-month course interferon treatment. Although the relationship between decreased HCV RNA titers within the first 2 days after one dose administration of interferon and the efficacy of the therapy was not obtained, the cases in which HCV RNA disappeared within 2 days significantly responded to the 6-month course treatment (73.7% vs 12.5% in other cases, p<0.01). The present study has confirmed the hypothesis suggested in the previous study that clearance of HCV RNA during the first 2 days has a predictive value for the final outcome.
収録刊行物
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- The Keio Journal of Medicine
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The Keio Journal of Medicine 46 (2), 74-80, 1997
The Keio Journal of Medicine
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詳細情報 詳細情報について
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- CRID
- 1390001206335026304
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- NII論文ID
- 10021987848
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- NII書誌ID
- AA00710216
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- COI
- 1:CAS:528:DyaK2sXltFChsrw%3D
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- ISSN
- 18801293
- 00229717
- http://id.crossref.org/issn/00229717
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- PubMed
- 9212590
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可